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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?

Fact Once model parameters have been determined with a single column system , they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns. Calculating key performance indicators (KPIs) for both single...
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Case studies & Application Notes

Application Note: Comparison of single column and MCSGP processes with mechanistic simulation

Application to oligonucleotides purification by ion exchange chromatography
The Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) process is a strong possible alternative to single-column chromatography for improving chromatographic process performances. Mechanistic simulations can provide an independent opinion...
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Case studies & Application Notes

Application Note: Prediction of an oligonucleotide purification by IEX thanks to simulation and mechanistic modeling

Impact of key operating parameters in a complex process
Designing a chromatographic process requires selecting numerous operating parameters (column dimensions, number of steps, step duration, buffer type, eluent pH, flowrates, gradient slope…) There is a high interest in using predictive simulation...
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Article : Digital tools unleash the full potential of oligonucleotide production

Panel Discussion on oligonucleotides in Chemistry Today
By Kilian Kobl - Project Manager at Ypso-Facto Current oligo manufacturing processes are still somewhat larger scale versions of the initial processes conceived in the lab. Oftentimes, during development of an API, the choice of speed had to be...
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Webinars

Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography

Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly...
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