Knowledge Center Highlights
INFORMATION & EXPERTISE
Ypso-Facto's Knowledge Center gathers a wealth of information on process development and optimization.
Explore our posters, dive into our scientific articles, and watch our webinars to discover our science-driven approach.
Case studies & Application Notes
Application Note: Prediction of the impact of buffer type with mechanistic simulation
Application to protein purification by IEX chromatography
The proper selection of buffers is essential in the design of ion exchange processes. It was reported...
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Webinars
Building a mechanistic model, guidelines and benefits with a focus on enzymatic reactions.
Presented by Yohann Le Guennec and Airy Tilland
Mechanistic models have provided great outcomes for chemical processes development and optimization...
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Webinars
Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography
Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing...
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Publications
Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?
By Roger-Marc Nicoud in Bioprocess International
In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became...
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Publications
Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation
Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography...
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Publications
Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised...
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Publications
Purification of Protein by HIC
Mechanistic Modeling for Improving Process Optimization
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the...
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Publications
CALIPSO: revolutionizing the management of bioproduction processes in healthcare
Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
A structuring R&D project for French medical research, financed and coordinated by a consortium...
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Publications
Oligonucleotide Purification by Ion-Exchange Chromatography: Predicting the Impact of Salt Type and Buffer pH with Mechanistic Modeling
Published in BioProcess International in collaboration with Roche
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography...
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Publications
Purification of a Viral Protein by Ion-Exchange Chromatography: Methodology for Mechanistic Modeling and Comparison with a Statistical Approach
Publication in BioProcess International
We developed a mechanistic model to simulate purification of a viral-protein complex by cation-exchange...
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Publications
Kinetic Modeling of Solid-Phase Oligonucleotide Synthesis: Mechanistic Insights and Reaction Dynamics
Publication in OPRD (Organic Process Research & Development)
Solid-phase oligonucleotide synthesis is a cornerstone of modern biotechnology, enabling the production...
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Blog
Modeling: Mechanistic or Statistical ? Part 1 : Modeling expectations
Digital tools are used for well-known applications in our everyday life: energy production, navigation...
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Blog
Three Benefits of Mechanistic Modeling For Chromatographic Process Development
Optimizing chromatographic processes can be achieved by employing mechanistic modeling, with the following...
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Blog
Mechanistic modeling completely replaces experiments: Myth or Fact?
Myth…for now
A mechanistic model relies on first principles based on physico-chemical phenomena...
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Blog
mAb production kinetics in CHO batch culture: exploring extracellular and intracellular dynamics
Publication in "Frontiers in Bioengineering and Biotechnology"
We are pleased to announce that Alejandro Avilan Garzon, PhD , doctoral researcher conducting his PhD...
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