Ypso-Facto Knowledge Center

Knowledge Center Highlights

Case studies & Application Notes

Application Note: Prediction of the impact of buffer type with mechanistic simulation

Application to protein purification by IEX chromatography
The proper selection of buffers is essential in the design of ion exchange processes. It was reported...
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Webinars

Building a mechanistic model, guidelines and benefits with a focus on enzymatic reactions.

Presented by Yohann Le Guennec and Airy Tilland
Mechanistic models have provided great outcomes for chemical processes development and optimization...
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Webinars

Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography

Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing...
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Publications

Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process

Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised...
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Publications

Purification of Protein by HIC

Mechanistic Modeling for Improving Process Optimization
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the...
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Publications

CALIPSO: revolutionizing the management of bioproduction processes in healthcare

Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
  A structuring R&D project for French medical research, financed and coordinated by a consortium...
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Blog

Modeling: Mechanistic or Statistical ? Part 1 : Modeling expectations

Digital tools are used for well-known applications in our everyday life: energy production, navigation...
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Blog

Three Benefits of Mechanistic Modeling For Chromatographic Process Development

Optimizing chromatographic processes can be achieved by employing mechanistic modeling, with the following...
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Blog

Mechanistic modeling completely replaces experiments: Myth or Fact?

Myth…for now A mechanistic model relies on first principles based on physico-chemical phenomena...
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