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Your Process Secured and Optimized… It’s a fact!
  • Simulation of chemical and biochemical processes
    We help you to develop and optimize (bio)processes ​with software suite and consulting services.
  • Simulation of chemical and biochemical processes
    Scientific publication on 'Purification of Protein by HIC : Mechanistic Modeling for Improving Process Optimization' with GSK
  • Simulation of chemical and biochemical processes
    Blog article on process modelisation : Exploring Mechanistic vs. Statistical Modeling.
  • Simulation of chemical and biochemical processes
    Three Benefits of Mechanistic Modeling For Chromatographic Process Development
    We investigate industrial processes with (bio)chemist eyes through process engineer glasses
    We assist you from the concept to the production via robust and innovative processes
  • Ypso Facto
    We combine industrial experience with scientific expertise to provide solutions at the cutting edge of science and technology

We develop, optimize and evaluate chemical and bioprocesses

Consulting services combined with simulation software to address your needs

Our mission

Ypso-Facto provides software tools as well as scientific & technical consulting related to chemical and biotechnological processes.

With a complementary know-how in (bio)chemistry, process engineering and software development, we help life science industries to develop, optimize and secure efficient and innovative processes. 

We support your manufacturing strategy from lab to production.

Increase Performances

Reach target performances: yield, purity, productivity…

Preserve Environnement

Minimize your environmental impact: waste reduction…

Make Rational decision

Make rational decision : identify a cost-effective process…

Enable Digitalisation

Drive your chemical and bioprocesses development into “a new era” with our tools.

Our team of experts

Ypso-Facto is a team with complementary expertise in (bio)chemistry, engineering and software development.
We associate a strong industrial experience with a high degree of scientific expertise allowing deep exploration of the challenges to find most suitable solutions. We are proud of having gathered a team offering different skills, experiences and cultures but sharing the same passion!

Ypso-Facto is always looking for dynamic and talented individuals. Contact us if you want to contribute to the adventure!

A synergistic offering


Technical and scientific consulting from short term assistance to long term collaboration.

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A range of software tools developed internally in the frame of our suite Ypso Proxima.

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of International


process evaluations


of activity
linked to chemistry


of revenues
dedicated to research

The GPX® concept

Leveraging three complementary means to address your challenges:

  • Guess – the ability of the experts to propose, anticipate, imagine… some routes or performances
  • Predictive Simulation – for a better understanding of your process to anticipate issues and make rational decisions
  • eXperimental data – the hard foundation of the project, which needs to be well targeted, structured and analyzed.
GPX concept

They trust us


2 min to discover Ypso-Facto

video : discover Ypso-Facto

Recent News

3 Benefits of Mechanistic Modeling For Chromatographic Process Development

  • November 23, 2023
 Mechanistic modeling is based on the laws of physics and biochemical principles to predict system behavior. It is the most advanced...

Coupling a macroscopic kinetic model with a flux balance analysis to model a mAb producing CHO culture

  • September 14, 2023
By  Alejandro AVILAN GARZON | Ypso-Facto/Université de Lorraine | France Date: 09-19-2023 , Time: 12:25 pm  |  Topic: H -...


TIDES Europe : Oligonucleotide and Peptide Therapeutics

  • September 05, 2023
Ypso-Facto will exhibit at  TIDES Europe , the industry's leading event in Europe to accelerate therapeutics to market by expediting R&D, improving CMC efficiency and building new partnerships.  ...

14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology

  • August 29, 2023
Chemical engineering, biotechnology and bioprocessing are the key to providing innovative solutions for food supply, mobility, energy, health and well-being while striving for a sustainable economy. At...

Last Publication

Purification of Protein by HIC

  • April 20, 2023
  • by Ypso-Facto
This article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.   Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main leverages identified to operate HIC processes are solution pH and ionic strength. In this article, the authors show that simplistic mathematical models derived from statistical analysis cannot describe the impact of pH and ionic strength observed in HIC processes. A new... Read more

Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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