We help develop, evaluate, and optimize (bio)chemical processes

Our proven methodology combines our/your expertise, well-targeted experiments, and predictive simulation to solve the biggest challenges in (bio)process development.

Your Process Secured and Optimized… It’s a Fact!

Our combined offering

Proxima Software Suite

Proxima Ionic
Design chromatographic processes
Proxima Basic design
Drawprocess diagrams and establish mass/heat balances
Proxima eval
Perform economic and environmental evaluation
Proxima Multistep
Describe your multistep synthesis within a chemist-friendly interface


  • Improve process performances such as yield, productivity, sustainability
  • Optimize experimental plans
  • Improve process understanding
  • Develop mechanistic models
  • Perform simulations as a service
  • Determine the design space
  • Troubleshoot existing processes

A Result oriented partner

Polypeptide Group

Reduced solvent consumption by 57% in peptide solid phase synthesis. Read more

Aker Biomarine

Doubled productivity of a multi-column ion exchange chromatographic process with increased purity. Read more


Re-established an antibiotic purification process that failed delivering the target purity following a change in raw material. Read more


Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process, while getting much more knowledge. Read more

They trust us

They speak about us

Recent News

Ypso-Facto cooperates with SmarSEP Industries to provide process modeling and numerical simulation services for the Chinese Industrial Biotechnology Market.

  • February 26, 2024
Ypso-Facto® (Nancy, France), a leading provider of (bio)chemical process simulation software and services, has announced a cooperation...

Ypso-Facto officially joins the ACCESS project

  • February 06, 2024
Ypso-Facto is proud to join officially the ACCESS project (Advanced Cell Control by Spectroscopic Sensors), a French R&D project...


Presentation on innovative chemical processes to students at the IUT of Illkirch

  • February 20, 2024
Last week, Kilian Kobl (Product Manager at Ypso-Facto) delivered a presentation at the IUT of Illkirch to third-year students, highlighting innovative chemical processes. He demonstrated how Proxima...

BioProcess International Europe

  • February 13, 2024
We are pleased to announce our participation in BioProcess International Europe , scheduled for April 9-12 in Vienna. This key event in biotechnology focuses on advancements in bioproduction, including...

Latest publications

Purification of Protein by HIC

  • April 20, 2023
  • by Ypso-Facto
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.   Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main leverages identified to operate HIC processes are solution pH and ionic strength. In this article, the authors show that simplistic mathematical models derived from statistical analysis cannot describe the impact of pH and ionic strength observed in... Read more

Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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