We help develop, evaluate, and optimize (bio)chemical processes

Our proven methodology combines our/your expertise, well-targeted experiments, and predictive simulation to solve the biggest challenges in (bio)process development.

Your Process Secured and Optimized… It’s a Fact!

Our combined offering

Proxima Software Suite

Proxima Ionic
Design chromatographic processes
Proxima Basic design
Drawprocess diagrams and establish mass/heat balances
Proxima eval
Perform economic and environmental evaluation
Proxima Multistep
Describe your multistep synthesis within a chemist-friendly interface


  • Improve process performances such as yield, productivity, sustainability
  • Optimize experimental plans
  • Improve process understanding
  • Develop mechanistic models
  • Perform simulations as a service
  • Determine the design space
  • Troubleshoot existing processes

A Result oriented partner

Polypeptide Group

Reduced solvent consumption by 57% in peptide solid phase synthesis. Read more

Aker Biomarine

Doubled productivity of a multi-column ion exchange chromatographic process with increased purity. Read more


Re-established an antibiotic purification process that failed delivering the target purity following a change in raw material. Read more


Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process, while getting much more knowledge. Read more

They trust us

They speak about us

Recent News

Ypso-Facto are pleased to announce that they got granted three families of patents

  • March 27, 2024
Ypso-Facto are pleased to announce that they got granted three families of patents in the last months: Method and device for...

Ypso-Facto cooperates with SmarSEP Industries to provide process modeling and numerical simulation services for the Chinese Industrial Biotechnology Market.

  • February 26, 2024
Ypso-Facto® (Nancy, France), a leading provider of (bio)chemical process simulation software and services, has announced a cooperation...


BPP 2024 Biopartitioning and Purification Conference

  • July 15, 2024
We are thrilled to announce that Ypso-Facto will be participating as a Platinum Sponsor at the BPP 2024 Biopartitioning and Purification Conference. This event, organized by the Luxembourg Institute...

Practical workshop with ENSAIA students using our Proxima software suite

  • May 28, 2024
This week concludes an enriching series of practical sessions with ENSAIA students, focusing on a project using our Proxima software suite. The project involved designing and evaluating a manufacturing...

Latest publications

Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation

  • April 12, 2024
  • by Ypso-Facto
  Check out  Ypso-Facto's new publication  on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK , Astrazeneca and Johnson & Johnson . ABSTRACT Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to significantly increased demand. Oligonucleotides are typically produced by solid-phase synthesis and then purified by ion exchange or reverse-phase chromatography. Predictive simulation is a valuable tool to help  reduce process development times, secure scale-up, and decrease... Read more

Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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