Proxima Software Suite: Ionic

Ionic: Designing Chromatographic Processes in a Virtual Lab

Ypso-Ionic® is an application in Ypso-Proxima® to design chromatographic processes.

Mechanistic chromatography modeling

Mechanistic modeling is based on the laws of physics and biochemical principles to predict system behavior and is the most advanced way to speed up chromatography process development, scale-up, and troubleshooting.

process understanding
Accelerate process understanding
process understanding
Reduce risk in scale-up and tech transfer
process understanding
Root cause analysis

About the name IONIC

Bioprocesses use buffers, and these buffers contain ions. Ion concentration and dissociation impact pH which in turns impacts molecules to be purified. Simultaneous interactions with the resin make the system very difficult to model.

Ionic is the only commercial software handling the complexity of ionization mechanisms in connection with chromatography.

This enables prediction of pH waves inside the column, simulation of interconnected columns, and influence of Critical Material Attributes as well as Critical Process Parameters.

Key features

Contextualize experimental data


  • Define your process (without restrictions in terms of recipe, number of columns, dead volumes, collection tanks, recycling…)
  • Store your measured results (both online and offline data) with adequate labels and units
  • Import protocols and data from specific equipment or from historical Excel files.


  • Ensure data standardization, completeness and reusability
  • Enjoy reliable tech transfer and knowledge management
  • Allow seamless connection with predictive simulation
experimental data

Compare and calculate KPIs in one-click


  • Automatically perform mass balance analysis from your data
  • Calculate KPIs (yield, purity, eluent consumption, productivity) on pooled fractions
  • Easily compare experiments


  • Save time
  • Reduce error-prone manual calculations
  • Remove ambiguities
compare kpi

Predict the impact of key parameters


  • Prediction of behaviors in non-explored regions thanks to mechanistic simulation
  • Examples of operating parameters: loading, flowrate, pH, salt nature and concentration, gradient slope, column dimensions, upflow vs downflow, number of columns


  • Narrow down the space where to focus on with experiments
  • Think out of the box
  • Secure scale-up
  • Perform troubleshooting
predict impact key parameters

A wide range of applications

Ionic can be used for various types of chromatography:
- Ion exchange, adsorption, affinity, hydrophobic interactions, size exclusion, ion exclusion, chelation, etc

… from the simplest to the most complex molecules:
mineral ions, sugars, organic acids, amino acids, oligonucleotides, proteins, monoclonal antibodies, etc

… with any kind of process configuration:
single-column or multicolumn, isocratic or gradient, backflush, with or without recycling, etc

Application notes & publications

More information?

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GPX® Concept - In order to address your challenges, we capitalize on 3 complementary means:

  • Guess- the ability of the experts to propose, anticipate, imagine… some routes or performances
  • Predictive Simulation – for a better understanding of your process to anticipate issues and make rational decisions
  • eXperimental data – the hard foundation of the project, which needs to be well targeted, structured and analyzed.

GPX concept

Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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