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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?

Fact Once model parameters have been determined with a single column system , they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns. Calculating key performance indicators (KPIs) for both single...
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Mechanistic modeling can help secure scale-up: Myth or Fact?

Fact Unlike statistical models which are based on correlations and are only valid for their calibration data set, mechanistic model parameters have an actual physical meaning and can be applied to different process setups and process scales. ...
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Blog

Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process

Customer Success Story from GSK
" GSK Engaged Ypso-Facto’s expertise, their Ypso-Ionic software and GPX approach to develop a mechanistic model of a complex ion-exchange purification process.    Compared with the classical statistical DoE approach, only 25% of the experimental...
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3 Benefits of Mechanistic Modeling For Chromatographic Process Development

 Mechanistic modeling is based on the laws of physics and biochemical principles to predict system behavior. It is the most advanced way to speed up chromatography process development, scale-up, and troubleshooting. Watch the Youtube video to discover...
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Doubled productivity of a multi-column ion exchange chromatographic process with increased purity

Customer Success Story from Aker BioMarine
About the optimization of a multi-column Ion Exchange system :   « In combination with AKBM “user-knowledge” and intuition, Ypso-Facto used experimental laboratory- and production-data and made simulation-models with the software...
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Blog

Three Benefits of Mechanistic Modeling For Chromatographic Process Development

Optimizing chromatographic processes can be achieved by employing mechanistic modeling, with the following benefits: Increase Process Understanding Get to the core of chromatography with mechanistic modeling. The combination of well targeted experiments...
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Publications

Purification of Protein by HIC

Mechanistic Modeling for Improving Process Optimization
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.   Hydrophobic interaction chromatography (HIC) is a separation technique widely used for...
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Blog

Discover Ypso-Ionic® in 3 minutes!

Open-up a new world of opportunities for your chromatographic processes
Working in downstream process development, do you:  interact with people of different skills and expectations? need to share information  in a standardized and non ambiguous manner? want to increase teamwork efficiency? If yes...
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Blog

Interviewing experts on DSP intensification

Process intensification allows biomanufacturers to produce more product, often more quickly, using fewer raw materials and smaller equipment in less space. While there has been much focus on upstream process intensification, this approach can have significant...
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Blog

Article : Intensifying Downstream Processes

Cynthia A. Challener - BioPharm International, April 2022 Issue
The need to increase efficiency and productivity is driving adoption. The biopharmaceutical industry is faced with the challenge of increasing efficiency and productivity to get needed medicines to patients more quickly and cost-effectively. Greater...
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Webinars

Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography

Presented by Kilian Kobl and illustrated with real-world examples from AstraZeneca and GSK
Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly...
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Blog

How to prepare your buffers in two clicks ?

Ypso-Ionic, the software solution for designing chromatographic processes
        Did you know that ...   In addition to maximizes the value of experimental data and makes predictive simulation a game changer , Ypso-Ionic software can help you prepare your buffers in two clicks ! Select...
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Blog

Maximize the value of your data and embrace the power of mechanistic simulation

Tired of working with Excel spreadsheets? With multiple and complex software tools limiting your efficiency? What if you could have a single solution to capture your data and run predictive simulation? We have good news for you:  Ypso-Ionic ,...
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Blog

Does pH matter in your separation process? 

  Do you work with mineral ions? With organic buffers? With proteins, peptides, or oligonucleotides whose retention behaviour is dramatically impacted by their charge?    Ypso-Ionic® is a software solution for ...
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Publications

CALIPSO: revolutionizing the management of bioproduction processes in healthcare

Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
  A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors. An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure...
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Case studies & Application Notes

Case Study: Removal of an odorous molecule in a cosmetic product

Process simulations using mechanistic modeling
Challenge Cosmetic active ingredient manufacturing process More stringent specifications in terms of the residual concentration of an odorous co-product Methods   Identification of relevant technologies for the removal...
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Case studies & Application Notes

Case Study: Design and start-up of a continuous purification process

  Challenge  Existing pilot batch process for the purification of omega-3 fatty acids from natural oil (11 unit operations) Shift to an industrial continuous production Methods Analysis of the existing batch...
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Webinars

Crystallization of polymorphs: advanced process monitoring, data analysis and mechanistic modeling for improved process understanding and optimization

Presented by Lucrèce Nicoud from Ypso-Facto and Richard Becker and Joe Oliva from Blaze Metrics
Many active pharmaceutical ingredients are known to crystallize in different polymorphic forms; a phenomenon that greatly impacts solubility, bioavailability, color, shape, filterability and tabletability. It is key to produce the targeted polymorph...
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Publications

Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process

Technical and economic evaluation to reduce Cost of Goods
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making...
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Blog

NEW ARTICLE – Fareva and Ypso-Facto investigate the purification of an antibiotic by ion-exchange

Using Mechanistic Modeling for Understanding Antibiotics Purification with Ion Exchange Chromatography
This article is based on a real industrial purification process by Fareva and highlights the power of mechanistic modeling for process development: Our client needed to change a raw material to secure his supply chain. From a process point of...
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Publications

Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability
ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key...
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Publications

Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister
Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex,...
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Publications

A continuum theory for multicomponent chromatography modeling

ABSTRACT: A continuum theory is proposed for modeling multicomponent chromatographic systems under linear conditions. The model is based on the description of complex mixtures, possibly involving tens or hundreds of solutes, by a continuum. The...
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Publications

Chromatographic Processes

Modeling, Simulation, and Design
ABSTRACT: Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions...
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