Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability

David Pfister, Lucrèce Nicoud, Massimo Morbidelli

  • by Ypso-Facto
  • September 22, 2018
Continuous Biopharmaceutical Processes


This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.



  1. Introduction to Biopharmaceutical Processes
  2. Fundamentals of Protein Chromatography
  3. Countercurrrent Separation Processes
  4. Countercurrent Chromatography for the Capture Step
  5. Countercurrent Chromatography for the Polishing Steps
  6. Protein Conjugation
  7. Protein Aggregation in Biopharmaceutical Processes
  8. Conclusion



Continuous Biopharmaceutical Processes - Chromatography, Bioconjugation, and Protein Stability, David Pfister, Lucrèce Nicoud, Massimo Morbidelli, 346 pages, Cambridge University Press, Cambridge Series in Chemical Engineering, New-York (2018), ISBN: 9781108420228.

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