Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation

Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson

  • by Ypso-Facto
  • April 12, 2024
  Check out  Ypso-Facto's new publication  on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK , Astrazeneca and Johnson & Johnson . ABSTRACT Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to significantly increased...

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Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?

By Roger-Marc Nicoud in Bioprocess International

  • by Ypso-Facto
  • March 07, 2024
In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became the first scientist to use chromatography to separate components of a solution (carotene pigments, in his case). Now, 120 years later, new airplanes can be simulated with great precision and confidence...

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Purification of Protein by HIC

Mechanistic Modeling for Improving Process Optimization

Lucrèce Nicoud, Yohann Le Guennec and Edouard Nicoud from Ypso-Facto; Antonio Cardillo, Alessandro Pieri and Elisa Innocenti from GSK; Elena Lietta from Politecnico di Torino.

  • by Ypso-Facto
  • April 20, 2023
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms.   Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main...

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CALIPSO: revolutionizing the management of bioproduction processes in healthcare

Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !

  • by Ypso-Facto
  • September 16, 2021
  A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors. An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure France’s competitiveness and its health independence...

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Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process

Technical and economic evaluation to reduce Cost of Goods

Thomas Prouzeau, Jerome Pezzini, and Benoit Mothes

  • by Ypso-Facto
  • January 15, 2021
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making. This article [1] illustrates the...

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