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WEBINAR - Associating digital tools and QbD to speed-up process development

  • by Ypso-Facto
  • March 26, 2021
Regulatory bodies, including the FDA and EMA, are strongly promoting the implementation of QbD: a science and risk-based approach to drug development and manufacturing to increase the success rate, process robustness and eventually product quality. In the meantime, different practitioners are a bit...

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WEBINAR - Using predictive digital tools to speed-up process development

A few simple and hopefully rational considerations.

  • by Ypso-Facto
  • March 11, 2021
In terms of digitalization, the biotech industries are quite significantly behind others, like the automotive or aeronautical industries, possibly because the digital tools available are not very well suited to their needs. Roger-Marc explains how numerical tools can support process development by...

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WEBINAR - Deuterium in the 21st century, use in medicinal chemistry and synthetic methods

  • by Ypso-Facto
  • March 09, 2021
Ninety years after its discovery, Deuterium is in the spotlight. Since the beginning of the 21st century, a number of biotechnology companies have successfully explored its potential in drug candidates and generated intellectual property. This approach has been ‘’validated’’ by the first approval...

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Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process

Technical and economic evaluation to reduce Cost of Goods

Thomas Prouzeau, Jerome Pezzini, and Benoit Mothes

  • by Ypso-Facto
  • January 15, 2021
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making. This article [1] illustrates the...

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Antibiotics purification by ion-exchange

The power of mechanistic modeling and predictive simulation

Lucrèce Nicoud, Karen-Vanessa Gonzalez, Aude Portier, and Roger-Marc Nicoud

  • by Ypso-Facto
  • November 02, 2020
  Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process. In the below article, you’ll see how some well-designed experiments and mechanistic...

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Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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