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Purification of Protein by HIC
Mechanistic Modeling for Improving Process Optimization
Lucrèce Nicoud, Yohann Le Guennec and Edouard Nicoud from Ypso-Facto; Antonio Cardillo, Alessandro Pieri and Elisa Innocenti from GSK; Elena Lietta from Politecnico di Torino.
This article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms. Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main leverages identified to...
CALIPSO: revolutionizing the management of bioproduction processes in healthcare
Paris (France) – September 16th, 2021 – Sanofi, Capgemini, Ypso-Facto, GPC Bio, CEA, CentralSupelec announce the launch of the project CALIPSO !
A structuring R&D project for French medical research, financed and coordinated by a consortium of high-profile industrial and public actors. An essential mobilisation to accelerate access to new treatments at an acceptable cost, to ensure France’s competitiveness and its health independence...
Process comparison in Ypso-Proxima: EASY by Sanofi vs. classical mAb purification process
Technical and economic evaluation to reduce Cost of Goods
Thomas Prouzeau, Jerome Pezzini, and Benoit Mothes
During the last years, alternatives to Protein A purification in mAb downstream processing have raised substantial interest. In parallel, the pharmaceutical industry has a growing need for reliable tools supporting process development and rational decision-making. This article [1] illustrates the...
Antibiotics purification by ion-exchange
The power of mechanistic modeling and predictive simulation
Lucrèce Nicoud, Karen-Vanessa Gonzalez, Aude Portier, and Roger-Marc Nicoud
Sometimes you have to change a raw material for various reasons (lack of availability, economic pressure, find alternative sustainable raw material), but this little change can impact significantly your process. In the below article, you’ll see how some well-designed experiments and mechanistic...
Oligonucleotides & Peptides
Peptide chemistry: in-silico development tools for an efficient process design
Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened without compromising on process performance and...
Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.
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