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Publications

Advanced SPPS

Discussion on the challenge of large-scale peptide synthesis on solid supports

Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto

  • by Ypso-Facto
  • January 24, 2019
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering the complexity of these multi-step syntheses, the...

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Understanding ion-exchange chromatography to design efficient processes with a predictive approach

IEX webinar

  • by Ypso-Facto
  • November 28, 2018
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was used to desalt sea water. Nowadays, industrial...

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A new era in life sciences software

The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling

Marc-Olivier Simon, Aline Devoille

  • by Ypso-Facto
  • November 22, 2018
"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector. Digitalisation or digital transformation is ubiquitous in discussions...

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Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability

David Pfister, Lucrèce Nicoud, Massimo Morbidelli

  • by Ypso-Facto
  • September 22, 2018
ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation...

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Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister

  • by Ypso-Facto
  • June 06, 2018
Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scalable, industrial success...

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Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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