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Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister

  • by Ypso-Facto
  • June 06, 2018
Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scalable, industrial success...

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Designing affinity chromatographic processes for the capture of antibodies

Part I: A simplified approach

D. Pfister, L. David, M. Holzer, R.-M. Nicoud*

  • by Ypso-Facto
  • March 22, 2017
ABSTRACT Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous systems. The design of such chromatographic...

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Comparing multi-column chromatographic processes for purifying monosaccharides

Part I: A simplifed approach

Laurent David, Jay Yun, Roger-Marc Nicoud*

  • by Ypso-Facto
  • March 14, 2017
ABSTRACT This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are...

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