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Publications

Oligonucleotides & Peptides

Peptide chemistry: in-silico development tools for an efficient process design

Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto

  • by Ypso-Facto
  • October 13, 2020
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened without compromising on process performance and...

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Advanced SPPS

Discussion on the challenge of large-scale peptide synthesis on solid supports

Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto

  • by Ypso-Facto
  • January 24, 2019
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering the complexity of these multi-step syntheses, the...

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Understanding ion-exchange chromatography to design efficient processes with a predictive approach

IEX webinar

  • by Ypso-Facto
  • November 28, 2018
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was used to desalt sea water. Nowadays, industrial...

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A new era in life sciences software

The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling

Marc-Olivier Simon, Aline Devoille

  • by Ypso-Facto
  • November 22, 2018
"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector. Digitalisation or digital transformation is ubiquitous in discussions...

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Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability

David Pfister, Lucrèce Nicoud, Massimo Morbidelli

  • by Ypso-Facto
  • September 22, 2018
ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation...

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Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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