Ypso Facto Publications

Designing affinity chromatographic processes for the capture of antibodies

Part I: A simpliﬁed approach

D. Pﬁster, L. David, M. Holzer, R.-M. Nicoud*

by Ypso-Facto
March 22, 2017

ABSTRACT Protein A afﬁnity chromatography is a standard technique for the puriﬁcation of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efﬁcient and continuous systems. The design of such chromatographic...

Comparing multi-column chromatographic processes for purifying monosaccharides

Part I: A simplifed approach

Laurent David, Jay Yun, Roger-Marc Nicoud*

by Ypso-Facto
March 14, 2017

ABSTRACT This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are...

Innovative organic chemistry: a differentiating driver for CMOs

A methodological approach to develop technical competitive advantages

Marc-Olivier Simon,* Roger-Marc Nicoud

by Ypso-Facto
October 28, 2016

ABSTRACT: The fine chemicals segment is a field of continuous innovation with regards to new molecular structures in which Contract Manufacturing Organizations (CMOs) play a major role, in particular for the commercial-scale production of organic molecules. To face constant international competition...

From batch to continuous processes: a good answer, but what is the question? Part II*

The purification unit operations, specific situations, the complete process perspective

Roger-Marc Nicoud

by Ypso-Facto
October 01, 2016

ABSTRACT: The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia on the topic, batch remains the widely accepted standard...