Contact us for a demo Follow us:
Oligonucleotide Purification by Ion-Exchange Chromatography: Predicting the Impact of Salt Type and Buffer pH with Mechanistic Modeling
Published in BioProcess International in collaboration with Roche
David Pfister, Lucrèce Nicoud, Ludivine Larue, Philipp Weber, Martin Olbrich
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with Roche. ABSTRACT Ion-exchange chromatography (IEC) is a common method for oligonucleotide purification (1, 2). Separation by IEC often uses strong–anion-exchange...
Ypso-Facto dans le magazine La Semaine : "L'entreprise biopharmaceutique Ypso-Facto, une réussite de Lorraine" (French)
Dans son dernier numéro, le magazine La Semaine consacre un article à Ypso-Facto. C’est l’occasion pour nous de partager un aperçu de notre travail et de notre engagement dans les secteurs de la chimie et des bioprocédés. L’article aborde notamment nos projets, notre approche et...
Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation
Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson
Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK, Astrazeneca and Johnson & Johnson. ABSTRACT Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to significantly increased...
Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?
By Roger-Marc Nicoud in Bioprocess International
In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became the first scientist to use chromatography to separate components of a solution (carotene pigments, in his case). Now, 120 years later, new airplanes can be simulated with great precision and...
Purification of Protein by HIC
Mechanistic Modeling for Improving Process Optimization
Lucrèce Nicoud, Yohann Le Guennec and Edouard Nicoud from Ypso-Facto; Antonio Cardillo, Alessandro Pieri and Elisa Innocenti from GSK; Elena Lietta from Politecnico di Torino.
In collaboration with GSK, this article outlines how a simple chromatographic model can predict the impact of pH and ionic strength on HIC chromatograms. Hydrophobic interaction chromatography (HIC) is a separation technique widely used for the purification of therapeutic proteins. The main...
Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.
© Ypso-Facto 2014 - Powered by Ealys | Legal Information