mAb production kinetics in CHO batch culture: exploring extracellular and intracellular dynamics

Publication in "Frontiers in Bioengineering and Biotechnology"

Alejandro Avilan Garzon, David Pfister (Ypso-Facto), Bruno Ebel, Samuel Schneider, Eric Olmos (université de Lorraine), Cédric Paris (LIBio)

• by Ypso-Facto
• August 13, 2025

We are pleased to announce that Alejandro Avilan Garzon, PhD, doctoral researcher conducting his PhD work at Ypso-Facto, has recently published part of his research in Frontiers in Bioengineering and Biotechnology, in collaboration with our colleague David Pfister. The study investigates key...

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Oligonucleotide Purification by Ion-Exchange Chromatography: Predicting the Impact of Salt Type and Buffer pH with Mechanistic Modeling

Published in BioProcess International in collaboration with Roche

David Pfister, Lucrèce Nicoud, Ludivine Larue, Philipp Weber, Martin Olbrich

• by Ypso-Facto
• May 21, 2025

  Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with Roche.   ABSTRACT Ion-exchange chromatography (IEC) is a common method for oligonucleotide purification (1, 2). Separation by IEC often uses strong–anion-exchange...

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Ypso-Facto dans le magazine La Semaine : "L'entreprise biopharmaceutique Ypso-Facto, une réussite de Lorraine" (French)

• by Ypso-Facto
• November 12, 2024

Dans son dernier numéro, le magazine La Semaine consacre un article à Ypso-Facto. C’est l’occasion pour nous de partager un aperçu de notre travail et de notre engagement dans les secteurs de la chimie et des bioprocédés. L’article aborde notamment nos projets, notre approche et...

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Oligonucleotide Purification by Ion Exchange Chromatography : Step-by-Step Guide to Process Understanding, Modeling, and Simulation

Published in OPRD in collaboration with GSK, AstraZeneca and Johnson & Johnson

• by Ypso-Facto
• April 12, 2024

  Check out Ypso-Facto's new publication on oligonuclotide purification by Ion Exchange Chromatography in collaboration with GSK, Astrazeneca and Johnson & Johnson. ABSTRACT Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to significantly increased...

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Bioprocess Simulation: Why the Industry Needs To Embrace Engineering Rather Than Empirical Approaches?

By Roger-Marc Nicoud in Bioprocess International

• by Ypso-Facto
• March 07, 2024

In 1903, the Wright brothers built the first functioning airplane, and botanist Mikhail Tsvet became the first scientist to use chromatography to separate components of a solution (carotene pigments, in his case). Now, 120 years later, new airplanes can be simulated with great precision and...

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