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Small molecules - Neutraceuticals - Antibodies - Antibiotics - Cosmetics - Enzymes - Oligonucleotides - Peptides - ProteinsBlog
What’s new in Ypso-Ionic®?
Ypso-Ionic is a reference software for computing the purification of biomolecules, oligonucleotides and peptides by chromatography. The charge of such molecules depends on pH, which is a key aspect to consider for running simulations. Ypso-Ionic...
Blog
Reduced solvent consumption by 57% in peptide solid phase synthesis
Customer Success Story from Polypeptide Group
"During our cooperation with Ypso -Facto, by associating our respective expertises , predictive simulation and experiments, we managed reducing by 57 % the solvent use for resin washing during SPPS ." Olivier LUDEMANN-...
Publications
Oligonucleotides & Peptides
Peptide chemistry: in-silico development tools for an efficient process design
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened...
Publications
Advanced SPPS
Discussion on the challenge of large-scale peptide synthesis on solid supports
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering...