Case Study: Design and start-up of a continuous purification process

by Ypso-Facto
July 08, 2021

Challenge

Existing pilot batch process for the purification of omega-3 fatty acids from natural oil (11 unit operations)
Shift to an industrial continuous production

Methods

Analysis of the existing batch system and elaboration of mass balances
Definition of technological choices
Selection of an equipment supplier to build the unit

Achievements

Successful transfer from a pilot batch process to a continuous commercial process (GMP manufacturing in an ATEX environment)
Assistance for the industrial unit start-up and the manufacturing of 3 validation batches

Ypso-Facto has been helping Pharmaceutical and Biopharmaceutical companies optimize their processes since 2014. We offer technology enabled services and proprietary software to solve some of our industries biggest challenges : make (bio)pharmaceutical processes safer, more cost efficient, and environmentally friendly.

We have a unique approach based on technologies which can combine multiple dimensions:

The educated guess or expertise of the experts, which we call G
The use and contextualization of experimental data, which we call X
And the predictive simulation based on mechanistic modelling, which we call P.

Depending on your product and process, we have mechanistic models that we can use, or we can work with your experimental data to build one. Altogether, that is our unique GPX approach.

#chromatography #mechanistic #modeling #simulation #purification #omega3 #naturaloil #continuous #processdevelopment #batch

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