Challenge: Scale-up of an industrial fermentation process required improved productivity and greater process stability.
Methods:
- Establishment of mass balances and calculation of yields and Oxygen Uptake Rates.
- Identification of key process parameters influencing performance.
- On-site support during the production campaign to monitor and adjust operations.
Achievements:
- Definition of a new protocol at pilot scale to secure scale-up.
- Real-time corrective actions implemented to address process deviations.
- Significant improvement in overall process performance.
Key message: Combining process analysis with on-site expertise enables robust scale-up and improved productivity for complex fermentation processes.