Case Study: Increasing yield and safety of a nitration process

• by Ypso-Facto
• March 15, 2022

Find out how our customers take advantage of our services to develop, optimize and secure their chemical, biochemical and bio-based processes.

Challenge

• 40-year old nitration process for the production of an Active Pharmaceutical Ingredient

• Highly complex process with low selectivity

• Need to enhance competitiveness and improve safety

Methods

• Analysis of existing performances and identification of the reaction pathway

• Predictive simulations coupling mass & heat transfer

• Reduction of impurity formation by optimizing the sequence of reactants loading and coupling the reaction with distillation

Achievements 

• Yield enhanced by a factor 4

• Safety largely improved by decreasing the reactor size (using a continuous tubular reactor)

  

At Ypso-Facto, we are convinced that the future of (bio)chemicals industries lays in more digitally designed processes. To achieve this transformation, we associate (bio)chemistry, process engineering and software development to help you through all phases of your projects. We can help you develop, optimize and secure your (bio)chemical processes with a synergistic offer: software tools and consulting services. 

 

#nitration #yield #saftey #process #processes #pharma #predictivesimulation 

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