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Mechanistic modeling can help switch from batch to continuous: Myth or Fact?

  • by Ypso-Facto
  • January 19, 2024
Mechanistic modeling can help switch from batch to continuous: Myth or Fact?

Fact

Once model parameters have been determined with a single column system, they can be used to perform simulations of multicolumn chromatography (MCC) with any number of columns.

Calculating key performance indicators (KPIs) for both single and multicolumn systems can help to compare options and make informed decisions

For example, we compared a Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) to a single-column process for oligonucleotide purification and assessed the impact of the number of columns on KPIs for monoclonal antibody capture. Discover the case study here.

If you want to learn more about mechanistic chromatography modeling, download our infography below.

Curious about more myths and facts in the world of mechanistic modeling? Each post in our series tackles common misconceptions and provides insightful answers to frequently asked questions. Check out the other posts in this series and others articles that might be of interest:



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