Comparison of single and multi-column processes with mechanistic simulation
Application to oligonucleotide purification by ion exchange
Multicolumn Chromatography is a strong possible alternative to single-column chromatography for improving process performances. Mechanistic simulations can be used to investigate several process options and quantify the impact on key performance indicators, thus providing a platform to make informed decisions prior to investing.
In this poster, we show an illustration of a rational comparison between the single-column process and the MCSGP process performed with the software Ypso-Ionic® applied to the example of oligonucleotide purification by ion exchange chromatography.
Take Home Message :
- Mechanistic simulation is a powerful tool capable of assessing several process options.
- The most suitable process for a given purification strongly depends on the objectives, constraints and levers of actions.
Click below to download the poster and delve deeper into the comparative analysis of single-column and multicolumn chromatography processes.