WEBINAR - Purification of protein by Hydrophobic Interaction Chromatography (HIC): mechanistic modeling for improved understanding and process optimization
Online, 5th May 2021
Hydrophobic Interaction Chromatography (HIC) is a chromatographic separation technique that is today successfully used for the purification of proteins. However, to achieve highly efficient separations, key operating parameters – like pH and ionic strength – must be well tuned. For this purpose, modeling tools can be of great help to minimize the experimental burden.
Yohann Le Guennec will demonstrate that statistic models derived from DOE analysis cannot reproduce pH and ionic strength effects observed in HIC, and are thus not adapted for HIC process development and optimization.
He will provide fundamentals on chromatography modeling and present a new mechanistic model that was shown to accurately describe experimental data. Lastly, he will illustrate how mechanistic modeling can improve process understanding and lead to the optimization of a HIC process performances.
DATE: Wednesday, May 5th, 2021
TIME: 3:00 PM (CEST) - 1:00 PM (GMT) - 9:00 AM (ET) - 6:00 AM (PT)
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