WEBINAR - Ion-Exchange Chromatography: Understanding and Modeling for Efficient Process Design

Ion-exchange chromatography is based on the differences in terms of electrostatic interactions of molecules regarding an adsorbent. Nowadays, industrial processes based on ion-exchange chromatography can be found in many different sectors from the food industry for sugars softening, to the biopharmaceutical industry for protein purification, to name only a few. While this technology is often considered too complex, industrial success stories proves the opposite.

 

In this webinar, Dr. Osuna, will speak about ion-exchange chromatography from a modeling point of view and show how and why “ion-exchange” is conceptually different from its cousin “adsorption”. Acido-basic equilibria and complexation reactions taking place in solution strongly impact the exchange mechanism with the charged surfaces thus leading to complex and intricated interactions. Based on the rigorous description of the physical phenomena at stake, predictive models can be derived to explain and quantify experimental observations that would otherwise look mysterious. Mechanistic models provide essential understanding and representation to design robust and efficient processes and pave the way towards a successful implementation of ion-exchange chromatography at all scales.