• Home
  • Events
  • TIDES Europe : Oligonucleotide and Peptide Development

TIDES Europe : Oligonucleotide and Peptide Development

16-18 November, Austria Center Vienna

  • by Ypso-Facto
  • September 05, 2022
TIDES Europe :  Oligonucleotide and Peptide Development

Ypso-Facto will exhibit at TIDES Europe, the industry's leading event in Europe to accelerate therapeutics to market by expediting R&D, improving CMC efficiency and building new partnerships. 

Access new data & case studies from speakers and companies across the entire landscape of oligonucleotides, peptides, mRNA, drug delivery and partnering strategies -- from discovery to market, with an emphasis on the European region.

Save the date : 16-18 November and meet us booth 4 in Austria Center Vienna

We would be delighted to meet with you and discuss your needs around peptides or oligonucleotides synthesis and purification

Should you be interested in improving target performances (yield, purity, productivity), minimizing your environmental impact or digital transformation, we have the expertise and relevant digital solutions to support your manufacturing strategy.

Book a meeting to learn more about our consulting services and software solutions : 


Poster presentation : Boosting a process with digital tools: purification of oligonucleotides by ion exchange 

Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly ion exchange chromatography. While APIs need to conform to strict purity requirements, most oligonucleotide ion exchange purifications are complex and not fully understood. This is a serious hurdle to reducing process development times, securing scale-up and decreasing waste generation. A digital approach allows overcoming such hurdles by allowing the prediction of the impact of key operating parameters e.g. on yield and purity as well as on raw material and solvent consumptions. 

Although a confusion is often made with adsorption chromatography for modeling purposes, it is essential to take account of the fundamental differences between ion exchange chromatography and adsorption. Furthermore, the high charge density and pH-dependent charge of oligonucleotides have prompted the need for developing a new powerful predictive model. We present a step-by-step methodology to use this model and illustrate it with real-world examples, leading pharmaceutical companies in the field. This methodology has been shown to lead to significant process understanding with a minimal experimental effort. 


Interested attendees may have a look at our last webinar: 

Getting your process up to speed with digital tools; purification of oligonucleotides by ion exchange chromatography

Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

Learn more

Contact Us
© Ypso-Facto 2014 - Powered by Ealys | Legal Information