- December 18, 2023
Reduced experimental work by 4 compared to DoE for an oligonucleotide ion exchange process
"GSK Engaged Ypso-Facto’s expertise, their Ypso-Ionic software and GPX approach to develop a mechanistic model of a complex ion-exchange purification process. Compared with the classical statistical DoE approach, only 25% of the experimental work was required, but we also achieved much more,...
- December 13, 2023
Mechanistic modeling is complex: Myth or Fact?
Myth The underlying equations that represent physical phenomena are necessarily complex, but using mechanistic models to gain process understanding doesn’t have to be. You don’t need to be a computerprogrammer or simulation expert with years of experience. With a clear methodology, a well-...
- December 06, 2023
Mechanistic modeling requires many experiments: Myth or Fact?
Myth A customer told us recently that mechanistic modeling required only 25% of the experimental work required for a classical statistical DoE approach and they also achieved much more, including deep process understanding. The number of experiments required depends on the objectives such as the...
- November 28, 2023
Mechanistic modeling completely replaces experiments: Myth or Fact?
Myth…for now A mechanistic model relies on first principles based on physico-chemical phenomena and requires estimating a number of model parameters specific to the case under investigation. The evaluation of model parameters is typically done based on a set of well targeted experiments. While...
- October 26, 2023
Doubled productivity of a multi-column ion exchange chromatographic process with increased purity
About the optimization of a multi-column Ion Exchange system: « In combination with AKBM “user-knowledge” and intuition, Ypso-Facto used experimental laboratory- and production-data and made simulation-models with the software “Ypso-Ionic”. With this GPX approach, Ypso-Facto...
- October 25, 2023
Three Benefits of Mechanistic Modeling For Chromatographic Process Development
Optimizing chromatographic processes can be achieved by employing mechanistic modeling, with the following benefits: Increase Process Understanding Get to the core of chromatography with mechanistic modeling. The combination of well targeted experiments with mechanistic simulations sheds...
- September 12, 2023
Reduced solvent consumption by 57% in peptide solid phase synthesis
"During our cooperation with Ypso-Facto, by associating our respective expertises, predictive simulation and experiments, we managed reducing by 57 % the solvent use for resin washing during SPPS." Olivier LUDEMANN-HOMBOURGER, Director Global - Innovation & Technology, PolyPeptide...
- June 12, 2023
Comparison of single and multi-column processes with mechanistic simulation
Multicolumn Chromatography is a strong possible alternative to single-column chromatography for improving process performances. Mechanistic simulations can be used to investigate several process options and quantify the impact on key performance indicators, thus providing a platform to make...
- May 08, 2023
Modeling: Mechanistic or Statistical ? Part 2 : Making a choice
Interested by knowing the differences between statistical and mechanistic approach? Click here to access part 1 of the article "Modeling : Mechanistic vs Statistical ? Part 1 : Modeling expectations" All modeling approaches need to be fed with experimental data to identify parameters. A...
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