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Continuous Biopharmaceutical Processes

Chromatography, Bioconjugation, and Protein Stability

David Pfister, Lucrèce Nicoud, Massimo Morbidelli

  • by Ypso-Facto
  • September 22, 2018
ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation...

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Designing Robust Chromatographic Processes with a Proven Predictive Approach

Webinar by David Pfister

  • by Ypso-Facto
  • June 06, 2018
Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scalable, industrial success...

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Designing affinity chromatographic processes for the capture of antibodies

Part I: A simplified approach

D. Pfister, L. David, M. Holzer, R.-M. Nicoud*

  • by Ypso-Facto
  • March 22, 2017
ABSTRACT Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous systems. The design of such chromatographic...

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Comparing multi-column chromatographic processes for purifying monosaccharides

Part I: A simplifed approach

Laurent David, Jay Yun, Roger-Marc Nicoud*

  • by Ypso-Facto
  • March 14, 2017
ABSTRACT This work proposes a methodology for comparing different multi-column chromatographic processes (SMB, ISMB, SSMB) for purifying monosaccharides. The first step of the methodology consists in determining the flow rates associated with the different processes assuming that the columns are...

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Innovative organic chemistry: a differentiating driver for CMOs

A methodological approach to develop technical competitive advantages

Marc-Olivier Simon,* Roger-Marc Nicoud

  • by Ypso-Facto
  • October 28, 2016
ABSTRACT: The fine chemicals segment is a field of continuous innovation with regards to new molecular structures in which Contract Manufacturing Organizations (CMOs) play a major role, in particular for the commercial-scale production of organic molecules. To face constant international competition...

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