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Understanding ion-exchange chromatography to design efficient processes with a predictive approach
IEX webinar
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited with the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to Ancient Egypt where it was used to desalt sea water. Nowadays, industrial...
A new era in life sciences software
The fine chemicals and biochemicals industries will evolve towards more digitally designed processes associating experiments, user know-how and mechanistic modeling
Marc-Olivier Simon, Aline Devoille
"Life sciences industries still use outdated tools and methodologies to develop, optimise and operate their (bio)molecule production processes. Ypso-Facto proposes to take a fresh look at the needs and expectations of this sector. Digitalisation or digital transformation is ubiquitous in...
Continuous Biopharmaceutical Processes
Chromatography, Bioconjugation, and Protein Stability
David Pfister, Lucrèce Nicoud, Massimo Morbidelli
ABSTRACT: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein...
Designing Robust Chromatographic Processes with a Proven Predictive Approach
Webinar by David Pfister
Preparative chromatography is a versatile purification technique used in various industrial sectors including petrochemistry, sugar production, pharmaceutical and fine chemistry, to name only a few. While this technology is often considered complex, expensive and sometimes not scalable, industrial...
Designing affinity chromatographic processes for the capture of antibodies
Part I: A simplified approach
D. Pfister, L. David, M. Holzer, R.-M. Nicoud*
ABSTRACT Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous systems. The design of such chromatographic...
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