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Publications

From batch to continuous processes: a good answer, but what is the question? Part I*

General considerations and the reaction unit perspective

Roger-Marc Nicoud

  • by Ypso-Facto
  • August 01, 2016
ABSTRACT: The switch from batch to continuous process is a major topical question in the fine chemical, pharmaceutical and biopharmaceutical industries. In spite of a genuine interest, as shown by the profusion of recent literature and symposia on the topic, batch remains the widely accepted standard...

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A continuum theory for multicomponent chromatography modeling

David Pfister, Massimo Morbidelli,* Roger-Marc Nicoud

  • by Ypso-Facto
  • March 22, 2016
ABSTRACT: A continuum theory is proposed for modeling multicomponent chromatographic systems under linear conditions. The model is based on the description of complex mixtures, possibly involving tens or hundreds of solutes, by a continuum. The present approach is shown to be very efficient when...

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Chromatographic Processes

Modeling, Simulation, and Design

Roger-Marc Nicoud

  • by Ypso-Facto
  • April 08, 2015
ABSTRACT: Addressing all aspects of the design, modeling and simulation of chromatographic processes, this result-oriented primer provides a practical guide to all the necessary approaches, methodologies and tools. Beginning with key definitions and concepts, it builds up from the most simple...

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The amazing ability of continuous chromatography to adapt to a moving environment

Roger-Marc Nicoud

  • by Ypso-Facto
  • February 17, 2014
ABSTRACT: While normally considered an expensive technology, chromatography has been used for very large-scale applications for ∼50 years. Main successes reported in the petrochemical or sugar industries are obtained with systems having the characteristics of being counter-current and continuous...

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Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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