Case Study: Improving an industrial fermentation

by Ypso-Facto
November 09, 2021

Challenge

Scale-up of a industrial fermentation process
Need to improve productivity and process stability

Methods

Establishment of mass balances, calculations of yields and Oxygen Uptake Rates
Identification of key process parameters
On site support during production campaign

Achievements

Definition of a new protocol at pilot scale
Real time corrective actions to address process deviations
Improvement of process performances

Ypso-Facto has been helping Pharmaceutical and Biopharmaceutical companies optimize their processes since 2014. We offer technology enabled services and proprietary software to solve some of our industries biggest challenges : make (bio)pharmaceutical processes safer, more cost efficient, and environmentally friendly.

We have a unique approach based on technologies which can combine multiple dimensions:

The educated guess or expertise of the experts, which we call G
The use and contextualization of experimental data, which we call X
And the predictive simulation based on mechanistic modelling, which we call P.

Depending on your product and process, we have mechanistic models that we can use, or we can work with your experimental data to build one. Altogether, that is our unique GPX approach.

#biotech #fermentation #scaleup #productivity #stability #pilotscale #software #mechanistic #modeling #simulation

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