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Purification of protein by Hydrophobic Interaction Chromatography (HIC): mechanistic modeling for improved understanding and process optimization

Presented by Yohann Le Guennec

  • by Ypso-Facto
  • May 06, 2021
Hydrophobic Interaction Chromatography (HIC) is a chromatographic separation technique that is today successfully used for the purification of proteins. However, to achieve highly efficient separations, key operating parameters – like pH and ionic strength – must be well tuned. For this purpose...

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Crystallization of polymorphs: advanced process monitoring, data analysis and mechanistic modeling for improved process understanding and optimization

Presented by Lucrèce Nicoud from Ypso-Facto and Richard Becker and Joe Oliva from Blaze Metrics

  • by Ypso-Facto
  • May 03, 2021
Many active pharmaceutical ingredients are known to crystallize in different polymorphic forms; a phenomenon that greatly impacts solubility, bioavailability, color, shape, filterability and tabletability. It is key to produce the targeted polymorph at a high purity and with the desired crystal properties...

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webinar Industry 4.0 : Using predictive digital tools to speed-up process development.

A few simple and hopefully rational considerations.

  • by Ypso-Facto
  • April 01, 2021
In terms of digitalization, the biotech industries are quite significantly behind others, like the automotive or aeronautical industries, possibly because the digital tools available are not very well suited to their needs. Roger-Marc explains how numerical tools can support process development by...

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