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Comparison of single and multi-column processes with mechanistic simulation

Application to oligonucleotide purification by ion exchange

  • by Ypso-Facto
  • June 12, 2023
Comparison of single and multi-column processes with mechanistic simulation

Multicolumn Chromatography is a strong possible alternative to single-column chromatography for improving process performances. Mechanistic simulations can be used to investigate several process options and quantify the impact on key performance indicators, thus providing a platform to make informed decisions prior to investing.

In this poster, we show an illustration of a rational comparison between the single-column process and the MCSGP process performed with the software Ypso-Ionic® applied to the example of oligonucleotide purification by ion exchange chromatography.

Take Home Message :

  • Mechanistic simulation is a powerful tool capable of assessing several process options.
  • The most suitable process for a given purification strongly depends on the objectives, constraints and levers of actions.  

Click below to download the poster and delve deeper into the comparative analysis of single-column and multicolumn chromatography processes.



Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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