Follow us:

News & events

  • Home
  • News & informations
  • NEW ARTICLE – Fareva and Ypso-Facto investigate the purification of an antibiotic by ion-exchange

NEW ARTICLE – Fareva and Ypso-Facto investigate the purification of an antibiotic by ion-exchange

Using Mechanistic Modeling for Understanding Antibiotics Purification with Ion Exchange Chromatography

  • by Ypso-Facto
  • November 02, 2020
NEW ARTICLE – Fareva and Ypso-Facto investigate the purification of an antibiotic by ion-exchange

This article is based on a real industrial purification process by Fareva and highlights the power of mechanistic modeling for process development:

Our client needed to change a raw material to secure his supply chain. From a process point of view, it was supposed to be seamless. However, a simple change of counter-ion made the separation completely inefficient and the separation process had to be redesigned completely.

When developing purification processes, ion-exchange chromatography is often approximated by classical adsorption models. However, in many cases, this inaccuracy fails to represent the system adequately, and finding a robust operating point proves very difficult – if not impossible!

In this example, two isomers of an antibiotic produced by fermentation were to be separated by ion-exchange chromatography.

A rational approach to ion-exchange and simulations using Ypso-Ionic® unlocked the process.

In particular, the study highlighted that the two isomers had very similar behaviors except in a narrow pH window around 9 where they bore different charges. The whole purification relied on this slight difference and only a rigorous ion-exchange model could represent the phenomena.

Read more about this study here: Using mechanistic modeling for understanding antibiotics purification with ion-exchange chromatography 


Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

Learn more

Contact Us
© Ypso-Facto 2014 - Powered by Ealys | Legal Information