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69th Starch Convention

Detmold, 10-11th April 2018

  • by Ypso-Facto
  • April 10, 2018
69th Starch Convention

Ypso-Facto will be at Demold Starch Conference. Join Laurent David's lecture:

"Using modeling to compare and optimize continuous chromatographic processes"


Sugar purification is one of the largest application of continuous chromatography and requires fine-tuned systems.

For instance, fructose is separated from glucose to produce High Fructose Corn Syrup (HFCS 55 and 42).

 These separations, typically performed on ion-exchange resins, are extremely productive: relatively linear adsorption isotherm enables very high feed concentration, up to 800 g/L.

The sugar market is extremely competitive, thus fine-tuning the system to maximize recovery, productivity and minimize water consumption is of utmost importance. 

We have developed advanced modeling tools and simulation software to understand the key drivers for optimization.1

 In spite of their relative linearity, the glucose and fructose adsorption isotherms are slightly anti-Langmuirian (the slope increases with concentration) and synergetic (increasing fructose concentration increases glucose adsorption and vice versa).

Using the so-called equilibrium model (triangle representation) and accounting for this uncommon adsorption behaviour, we identify SMB parameters that are critical for the required separation, and we show that fructose can be purified and concentrated at the same time.

An alternative process is also investigated where fructose is purified at 90 % (instead of 55%) and a by-pass is used to obtain the targeted 55 %.

Both processes are compared in terms of equilibrium model.

Finally, using ChromWorksTM,1  SMB, S-SMB, I-SMB and new innovative custom multi-column configurations are designed, the critical parameters are identified for each and their performances are predicted, allowing for a rational comparison of these systems.


  1. ChromWorksTM, a modeling and simulation software for chromatographic separations, Ypso-Facto, Nancy, France


Ypso-Facto is a service company helping industrial firms to develop, optimize and secure their chemical processes and bioprocesses.

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