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IOPC : International oligonucleotides and peptides conference

27-29 June, 2022 - Milan, Italy

  • by Ypso-Facto
  • May 05, 2022
IOPC : International oligonucleotides and peptides conference

Ypso-Facto will attend the 3rd edition of  the International Oligonucleotides and Peptides Conference – IOPC 2022. The IOPC 2022 agenda features 2 parallel tracks covering the following sessions:

  • OLIGONUCLEOTIDES : chemical diversity and synthetic issues, delivery and formulation, preclinical studies, clinical updates
  • PEPTIDES : manufacturing upstream, purification, drug discovery of the future, alternative applications, drug delivery and formulation, peptides material

Do not miss our presentation in the oligonucleotides session : Boosting a process with digital tools: purification of oligonucleotides by ion exchange! Save the date : Tuesday, June 28th - 5:30 PM-5:50 PM

Abstract : Oligonucleotides have emerged as a promising class of pharmaceuticals, leading to a drastically increasing demand. Like peptides, they are typically produced by solid phase synthesis and then purified by reverse-phase chromatography and increasingly ion exchange chromatography. While APIs need to conform to strict purity requirements, most oligonucleotide ion exchange purifications are complex and not fully understood. This is a serious hurdle to reducing process development times, securing scale-up and decreasing waste generation. A digital approach allows overcoming such hurdles by allowing the prediction of the impact of key operating parameters e.g. on yield and purity as well as on raw material and solvent consumptions.

Although a confusion is often made with adsorption chromatography for modeling purposes, it is essential to take account of the fundamental differences between ion exchange chromatography and adsorption. Furthermore, the high charge density and pH-dependent charge of oligonucleotides have prompted the need for developing a new powerful predictive model. We have developed a step-by-step methodology on real-world cases in collaboration with leading pharmaceutical companies in the field. This methodology has been shown to lead to significant process understanding with a minimal experimental effort.

Contact us to book a meeting and discuss about your own challenges!

 


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