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Oligonucleotides & Peptides

Peptide chemistry: in-silico development tools for an efficient process design

Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto

  • by Ypso-Facto
  • October 13, 2020
ABSTRACT This article highlights a new way of thinking for the optimization of Peptide Synthesis. The concept is based on numerical tools to assist the peptide chemists for the choice of the manufacturing route. Process development can be shortened without compromising on process performance and...

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Advanced SPPS

Discussion on the challenge of large-scale peptide synthesis on solid supports

Olivier Ludemann-Hombourger of PolyPeptide Laboratories and N. Petitjean of Ypso-Facto

  • by Ypso-Facto
  • January 24, 2019
"Solid-Phase Peptide Synthesis (SPPS) is well established and routinely applied on efficient automatic synthesisers, which are available at laboratory scale. However, manufacturing peptides at industrial scale remains a major challenge, considering the complexity of these multi-step syntheses, the...

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Understanding ion-exchange chromatography to design efficient processes with a predictive approach

IEX webinar by Dr Hector Osuna

  • by Ypso-Facto
  • November 28, 2018
Ion-exchange chromatography is certainly the most ancient type of chromatography. While M. Tswett is often credited the paternity of chromatography, the first traces of the use of ion-exchange chromatography date back to the Ancient Egypt where it was used to desalt see water. Nowadays, industrial processes...

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